(click on text to download PDF)

Nystrom SL, Niederhuber MJ, McKay DJ. The temporal transcription factor E93 controls dynamic enhancer activity and chromatin accessibility during development. BioRxiv2019.

Ma Y, McKay DJ, Buttitta L. Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells. PLoS Biology. 2019 Sep 3;17(9):e3000378. PMID: 31479438.

McKay DJ, Stutzman AV, Dowen JM. Advancements in mapping 3D genome architecture. Methods. 2020 Jan 1;170:75-81. Review. PMID: 31201934.

Poulton JS, McKay DJ, Peifer M. Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress. Genetics. 2019 May;212(1):187-211. PMID: 30867197.

Uyehara CM, McKay DJ. Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila. Proc Natl Acad Sci USA. 2019 Apr 24. PMID: 31019084.

Leatham-Jensen M, Uyehara CM, Strahl BD, Matera AG, Duronio RJ, McKay DJ. Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation. PLoS Genetics. 2019 Jan;15(1):e1007932. PMCID: PMC6370247.

McKay DJ. Using Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) to Identify Functional Regulatory DNA in Insect GenomesMethods in Molecular Biology. 2019; 1858. PMID: 30414113

Armstrong RL, Penke TJR, Strahl BD, Matera AG, McKay DJ, MacAlpine DM, Duronio RJ. Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. Genome Research. 2018; 28(11). PMID: 30279224

Meers MP, Leatham-Jensen M, Penke TJR, McKay DJ, Duronio RJ, and Matera AG. An animal model for genetic analysis of multi-gene families:  Cloning and transgenesis of large tandemly-repeated histone gene clusters. Methods in Molecular Biology. 2018; 1832. PMID: 30073535.

Lai YT, Deem KD, Borràs-Castells F, Sambrani N, Rudolf H, Suryamohan K, El-Sherif E, Halfon MS, McKay DJ, Tomoyasu Y. Enhancer identification and activity evaluation in the red flour beetle, Tribolium castaneum. Development. 2018; 145(7). PMID: 29540499.

Meers MP, Adelman K, Duronio RJ, Strahl BD, McKay DJ, Matera AG. Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC genomics. 2018; 19(1):157. PMCID: PMC5822475

Penke TJR, McKay DJ, Strahl BD, Matera AG, Duronio RJ. Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila. Genetics. 2018; 208(1):229-244. PMCID: PMC5753860

Uyehara CM, Nystrom SL, Niederhuber MJ, Leatham-Jensen M, Ma Y, Buttitta LA, McKay DJ. Hormone-dependent control of developmental timing through regulation of chromatin accessibility. Genes & Development. 2017 May 1;31(9):862-875. PMCID: PMC5458754.  Outlook by Carl Thummel.

Meers MP, Henriques T, Lavender CA, McKay DJ, Strahl BD, Duronio RJ, Adelman K, Matera AG. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Elife. 2017 Mar 27;6. pii: e23249. doi: 10.7554/eLife.23249. PMCID: PMC5404926.

Guo Y, Flegel K, Kumar J, McKay DJ, Buttitta LA. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biology Open. 2016 Nov 15;5(11):1648-1661. doi: 10.1242/bio.017525. PMCID: PMC5155522.

Pearson JC*, McKay DJ*#, Lieb JD, and Crews ST#. Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers. Development. 2016 Oct 15;143(20):3723-3732. PMCID: PMC5087646.

Penke TJ, McKay DJ, Strahl BD, Matera AG, Duronio RJ. Direct interrogation of the role of H3K9 in metazoan heterochromatin function. Genes & Development. 2016; 30(16):1866-80. PMID: 27566777.

Tatomer DC, Terzo E, Curry KP, Salzler H, Sabath I, Zapotoczny G, McKay DJ, Dominski Z, Marzluff WF, Duronio RJ. Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis. The Journal of Cell Biology. 2016; 213(5):557-70. PMID: 27241916.

Schulz KN, Bondra ER, Moshe A, Villalta JE, Lieb JD, Kaplan T, McKay DJ, Harrison MM. Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryoGenome Research. 2015; 25(11):1715-26. PMID: 26335634.

McKay DJ, Klusza S, Penke TJR, Meers MP, Curry KP, McDaniel SL, Malek PY, Cooper SW, Tatomer DC, Lieb JD, Strahl BD, Duronio RJ, Matera AG. Interrogating the function of metazoan histones using engineered gene clusters. Developmental Cell. 2015; 32: 373-386. PMID 25669886.

McKay DJ, Lieb JD. A split personality for nucleosomes. Interrogating the function of metazoan histones using engineered gene clusters. Cell. 2014; 159: 1249-1251. PMID 25480289.

Agelopoulos M, McKay DJ, Mann RS. cgChIP: a cell type- and gene-specific method for chromatin analysis. Methods in Molecular Biology. 2014; 1196:291-306. PMID 25151171.

McKay DJ#, Lieb JD#. A common set of DNA regulatory elements shapes Drosophila appendages. Developmental Cell. 2013; 27: 306-318. PMID: 24229644.              (highlighted in Nature Genetics)

Agelopoulos M, McKay DJ, Mann RS. Developmental regulation of chromatin conformation by Hox proteins in Drosophila. Cell Reports. 2012; 1: 350-359. PMCID: PMC3329935.

Roberts DM, Pronobis MI, Alexandre KM, Rogers GC, Poulton JS, Schneider DE, Jung KC, McKay DJ, Peifer M. Defining components of the beta-catenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS One. 2012; 7: e31284. PMCID: PMC3281067.

Nolis IK*, McKay DJ*, Mantouvalou E, Lomvardas S, Merika M, Thanos D. Transcription factors mediate long-range enhancer-promoter interactions. Proc Natl Acad Sci USA. 2009; 106: 20222-20227. PMCID: PMC2779200.

McKay DJ*, Estella C*, Mann RS. The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene. Development 2009; 136:  61-71. PMCID:  PMC2653810.

Estella C*, McKay DJ*, Mann RS. Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. Developmental Cell 2008; 14: 86-96. PMCID: PMC2709787.

Noro B, Culi J, McKay DJ, Zhang W, Mann RS. Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes and Development 2006; 20: 1636-1650. PMCID:  PMC1482483.

Gebelein B, McKay DJ, Mann RS. Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature 2004; 431: 653-659. PMID 15470419.


McKay_research_image (2)