Developmental enhancers identified by open chromatin profiling in Drosophila embryos and imaginal discs.
Genomics of gene regulation in Drosophila development.
Research in the lab is centered on the fundamental question of how a single genome gives rise to a variety of cell types and body parts during development. We seek to understand how information encoded in the DNA sequence is selectively accessed at the proper time and place. We study this question following two lines of investigation:
- Control of chromatin accessibility by transcription factors.
- Epigenetic regulation of transcription by histone post-translational modifications.
We focus on the mechanisms of transcriptional regulation, using a combination of genomics, Drosophila genetics, microscopy, and biochemistry.