We focus on the central question of how access to transcriptional regulatory information is controlled to generate and maintain a diversity of cell types and body parts during development. There are two main projects in the lab:
Project 1: Dynamic control of DNA regulatory elements.
The objective of this project is to determine how transcription factors physically access cis-regulatory elements in the genome during development. In other words, what mechanisms determine where and when enhancers are switched on and off in developing tissues? (read more).
Project 2: The role of histones as carriers of epigenetic information in animals.
The objective of this project is to determine the contribution made by histone post-translational modifications (PTMs) in propagating information independent of DNA sequence (read more).